产品货号：
Z23141
中文名称：
PADI4抗体
英文名称：
Anti-PADI4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PADI4 Antibody |
| 指标别名 | HL 60 PAD;PAD;PAD4;PADI4;PADI5;PDI4;PDI5;Peptidylarginine deiminase IV |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | PADI4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human PADI4(492-512aa ASPRSCYKLFQEQQNEGHGEA). |
| 实际分子量 | 68KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PADI4(Peptidylarginine Deiminase,Type IV),also known as PAD or PAD4,is a human protein which in humans is encoded by the PADI4 gene.Peptidylarginine deiminases,such as PADI4,make up a family of posttranslational modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ion(Nakashima et al.,1999).Suzuki et al.(2003) found from sequence data that the PADI4 gene maps to 1p36.Cuthbert et al.(2004) described a process,deimination,that converts histone arginine to citrulline and antagonizes arginine methylation.They showed that PADI4 specifically deiminated arg2,arg8,arg17,and arg26 in the H3 tail.Deimination by PADI4 prevented arginine methylation by CARM1.Dimethylation of arginines prevented deimination by PADI4,although monomethylation still allowed deimination to take place.In vivo targeting experiments on an endogenous promoter demonstrated that PADI4 could repress hormone receptor-mediated gene induction.PADI4 was recruited to the pS2 promoter following hormone induction when the gene was transcriptionally downregulated,consistent with a repressive role for PADI4. |
| Uniprot ID | Q9UM07 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | peptidyl arginine deiminase,type IV |
| 蛋白名全称 | Protein-arginine deiminase type-4 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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